Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 0.575


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TAL1hg19_v1_chr1_-_47695442_476954420.431.4e-04Click!
TCF12hg19_v1_chr15_+_57210972_572110290.421.7e-04Click!
TCF3hg19_v1_chr19_-_1652327_1652352-0.351.9e-03Click!
TCF4hg19_v1_chr18_-_53071225_530712250.152.0e-01Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_150738232 2.657 CTSS
cathepsin S
chr1_-_150738255 2.449 CTSS
cathepsin S
chr10_-_73848530 2.061 NM_001244950
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr1_-_150738292 1.983 NM_001199739
NM_004079
CTSS

cathepsin S

chr6_-_163148716 1.896 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr10_-_73848766 1.800 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr2_+_152214105 1.800 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_-_23521221 1.718 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr1_-_205391180 1.693 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr6_-_163148798 1.679 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr2_-_225811730 1.656 DOCK10
dedicator of cytokinesis 10
chr6_-_163148759 1.629 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr1_+_116380404 1.581 NHLH2
nescient helix loop helix 2
chr5_+_147443534 1.456 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr6_+_163149001 1.370 NM_001080379
PACRG
PARK2 co-regulated
chr12_-_62586547 1.357 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chrX_-_154563735 1.357 NM_001289
CLIC2
chloride intracellular channel 2
chr2_-_183387063 1.277 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr11_-_85469043 1.152 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr17_-_47286742 1.147 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr9_+_12774988 1.139 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr10_-_14050453 1.087 FRMD4A
FERM domain containing 4A
chr13_-_27334777 1.049 NM_005288
GPR12
G protein-coupled receptor 12
chr19_+_15904760 1.024 NM_001004466
OR10H5
olfactory receptor, family 10, subfamily H, member 5
chr11_-_58611979 0.981 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr1_+_92632608 0.969 NM_015237
KIAA1107
KIAA1107
chr11_-_62689011 0.917 NM_000738
CHRM1
cholinergic receptor, muscarinic 1
chr17_+_43238263 0.903 NM_144608
HEXIM2
hexamethylene bis-acetamide inducible 2
chr11_-_62688732 0.832 CHRM1
cholinergic receptor, muscarinic 1
chr9_+_72658496 0.831 NM_153267
MAMDC2
MAM domain containing 2
chr4_-_76957139 0.814 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr6_+_126240369 0.812 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr1_-_177939049 0.804 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr5_-_176326314 0.803 NM_002115
HK3
hexokinase 3 (white cell)
chr22_+_31003069 0.790 NM_000355
NM_001184726
TCN2

transcobalamin II

chr3_+_111718006 0.758 NM_001008273
TAGLN3
transgelin 3
chr16_+_57728711 0.744 NM_032269
CCDC135
coiled-coil domain containing 135
chr16_+_4606490 0.731 NM_001145011
C16orf96
chromosome 16 open reading frame 96
chr6_-_42690308 0.719 NM_000322
PRPH2
peripherin 2 (retinal degeneration, slow)
chr17_+_41003360 0.710


chr17_+_41003184 0.709 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr7_+_76139744 0.700 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr5_+_53751430 0.686 NM_006308
HSPB3
heat shock 27kDa protein 3
chr16_+_2588000 0.678 PDPK1
3-phosphoinositide dependent protein kinase-1
chr14_-_94849552 0.672 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr11_-_16497917 0.650 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr6_-_163148800 0.634 NM_004562
NM_013987
NM_013988
PARK2


parkinson protein 2, E3 ubiquitin protein ligase (parkin)


chr15_+_25101697 0.611 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr19_-_12997956 0.606 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr3_+_195447810 0.604 MUC20
mucin 20, cell surface associated
chr22_+_24979717 0.598 NM_013430
GGT1
gamma-glutamyltransferase 1
chr16_+_2587989 0.587 PDPK1
3-phosphoinositide dependent protein kinase-1
chr2_-_158300517 0.580 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_-_11382501 0.576 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr9_+_12775713 0.572 C9orf150
chromosome 9 open reading frame 150
chr17_-_67057046 0.566 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr16_+_78056411 0.543 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr11_-_75141517 0.540 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr4_-_72669757 0.517 NM_001204307
GC
group-specific component (vitamin D binding protein)
chr12_-_48119224 0.516 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr17_-_56406120 0.508 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr6_-_66417069 0.507 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr8_-_68658577 0.500 NM_020361
CPA6
carboxypeptidase A6
chr12_-_103311380 0.499 NM_000277
PAH
phenylalanine hydroxylase
chr19_+_53547990 0.494 NM_001191055
ERVV-2
endogenous retrovirus group V, member 2
chr5_+_173472692 0.494 NM_015980
HMP19
HMP19 protein
chr11_+_1213469 0.492 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr1_-_160681552 0.489 NM_001778
CD48
CD48 molecule
chr1_+_32716839 0.482 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr16_-_29910340 0.473 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr5_-_142784102 0.470 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr9_-_35870316 0.469 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr11_+_67222817 0.456 NM_145200
CABP4
calcium binding protein 4
chr10_-_50122279 0.438 NM_001006939
LRRC18
leucine rich repeat containing 18
chr13_+_108922205 0.438 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr5_+_140220811 0.436 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr4_-_20985547 0.423 KCNIP4
Kv channel interacting protein 4
chr19_+_17638064 0.413 FAM129C
family with sequence similarity 129, member C
chr22_-_36600759 0.413 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr6_-_41122025 0.412 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr19_-_15918848 0.407 NM_013940
OR10H1
olfactory receptor, family 10, subfamily H, member 1
chrX_+_38211735 0.406 NM_000531
OTC
ornithine carbamoyltransferase
chr13_+_113741668 0.393 MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_-_56296965 0.389 NM_001165927
MKS1
Meckel syndrome, type 1
chr2_-_89513056 0.389 IGKC
immunoglobulin kappa constant
chr1_+_209878135 0.388 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_+_19934573 0.384


chr17_+_73629513 0.383 NM_001162995
C17orf109
chromosome 17 open reading frame 109
chr8_+_9413390 0.381 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr9_+_72658735 0.376 MAMDC2
MAM domain containing 2
chr2_+_191301020 0.373 MFSD6
major facilitator superfamily domain containing 6
chr5_-_131879172 0.370 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr18_+_6834431 0.366 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr7_+_113726364 0.360 FOXP2
forkhead box P2
chr5_+_173472737 0.358 HMP19
HMP19 protein
chr1_-_145715561 0.356 NM_007053
CD160
CD160 molecule
chr10_-_73848309 0.356 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chrX_+_128913881 0.347 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_-_120935943 0.345 NM_001004340
NM_001017986
NM_001244910
FCGR1A
FCGR1B


Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)


chr13_+_108922560 0.342 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr7_-_99527242 0.321 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr9_-_104357202 0.318 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr2_-_136288768 0.318 NM_032143
ZRANB3
zinc finger, RAN-binding domain containing 3
chr11_+_6128913 0.317 NM_001005181
OR56B4
olfactory receptor, family 56, subfamily B, member 4
chr20_-_58507172 0.313 NM_014258
SYCP2
synaptonemal complex protein 2
chr19_-_11688441 0.313 ACP5
acid phosphatase 5, tartrate resistant
chr3_-_10332408 0.310 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr9_+_35673852 0.304 NM_001216
CA9
carbonic anhydrase IX
chr2_+_232120777 0.302


chr2_+_108994366 0.299 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr11_+_117103237 0.298 NM_207343
NM_001077239
RNF214

ring finger protein 214

chr16_+_2587951 0.296 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chr22_-_36556781 0.294 NM_145640
APOL3
apolipoprotein L, 3
chr5_-_142783975 0.294 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr19_+_45417920 0.283 NM_001645
APOC1
apolipoprotein C-I
chrX_+_103031753 0.283 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr3_-_114478117 0.281 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr3_-_190167597 0.280 NM_207316
TMEM207
transmembrane protein 207
chr13_+_108921976 0.279 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr17_+_6659155 0.276 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chrX_+_48242967 0.275 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr12_+_27619742 0.274 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chrX_+_128872924 0.273 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr17_-_56606534 0.272 SEPT4
septin 4
chr13_+_108922474 0.268 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr8_+_9413439 0.267 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr15_-_31453382 0.265 NM_001252020
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr8_+_9413422 0.265 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr19_+_51760963 0.263 NM_173635
C19orf75
chromosome 19 open reading frame 75
chr7_+_113726490 0.262 FOXP2
forkhead box P2
chr6_-_31514393 0.258 ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chrX_-_2886285 0.257 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr7_-_37025696 0.256 ELMO1
engulfment and cell motility 1
chr5_-_93077196 0.253 NM_153216
POU5F2
POU domain class 5, transcription factor 2
chr17_-_46035109 0.253 NM_024320
PRR15L
proline rich 15-like
chrX_+_103031797 0.253 PLP1
proteolipid protein 1
chr1_+_109102970 0.250 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr7_+_155437143 0.247 RBM33
RNA binding motif protein 33
chr3_+_10068123 0.246 FANCD2
Fanconi anemia, complementation group D2
chr11_+_5602106 0.245 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chrX_+_125953746 0.244 NM_001122716
CXorf64
chromosome X open reading frame 64
chr9_-_28719302 0.244 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr16_+_12058963 0.244 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr7_+_149473130 0.243 NM_198455
SSPO
SCO-spondin homolog (Bos taurus)
chr12_-_123187842 0.243 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr16_+_21716283 0.242 NM_170664
OTOA
otoancorin
chr22_+_24115035 0.239 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr3_-_178984789 0.237 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr9_-_107367907 0.234 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr6_-_127780534 0.233 NM_014702
KIAA0408
KIAA0408
chr17_-_72542244 0.230 NM_006678
CD300C
CD300c molecule
chr16_+_58010338 0.226 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr1_-_17307107 0.224 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr7_+_18548899 0.224 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr3_+_96533424 0.222 NM_001080448
EPHA6
EPH receptor A6
chr17_-_39156106 0.220 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr6_-_31514620 0.217 NM_001204078
NM_130463
NM_138282
ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chr2_-_26541916 0.215 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chrY_+_20708556 0.215 NM_153716
NM_001001877
NM_033108
NM_152584
HSFY2

HSFY1

heat shock transcription factor, Y linked 2

heat shock transcription factor, Y-linked 1

chr3_-_149095517 0.215 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr7_-_76038894 0.214 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr9_+_131683173 0.214 NM_001100876
NM_174933
PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

chr4_-_69434215 0.211 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr12_-_64616032 0.211 NM_152440
C12orf66
chromosome 12 open reading frame 66
chr17_-_73937105 0.209 NM_001080542
FBF1
Fas (TNFRSF6) binding factor 1
chr16_-_20338808 0.207 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr7_+_18548963 0.203 HDAC9
histone deacetylase 9
chr20_-_1638359 0.201 NM_001039508
NM_018556
NM_080816
SIRPG


signal-regulatory protein gamma


chr20_-_45179212 0.200 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr8_+_74903563 0.200 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr12_+_7456927 0.199 NM_001080454
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr19_-_45826232 0.195 NM_001824
CKM
creatine kinase, muscle
chr9_-_100707102 0.194 NM_018437
HEMGN
hemogen
chr7_+_127233688 0.191 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr9_-_19033183 0.191 NM_153707
FAM154A
family with sequence similarity 154, member A
chr3_+_10068139 0.190 FANCD2
Fanconi anemia, complementation group D2
chr12_+_57388229 0.190 NM_007264
GPR182
G protein-coupled receptor 182
chrX_+_128913897 0.189 SASH3
SAM and SH3 domain containing 3
chr17_-_47925378 0.189 NM_001077503
NM_001077504
NM_001077505
NM_001077506
NM_170685
TAC4




tachykinin 4 (hemokinin)




chr5_-_135290521 0.189 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr11_+_5775922 0.188 NM_001005175
OR52N4
olfactory receptor, family 52, subfamily N, member 4
chrX_+_69509878 0.187 NM_012310
KIF4A
kinesin family member 4A
chr7_+_63505820 0.187 NM_001159522
ZNF727
zinc finger protein 727
chr6_-_32160289 0.184 GPSM3
G-protein signaling modulator 3
chr12_-_103310896 0.184 PAH
phenylalanine hydroxylase
chr21_-_45682098 0.183 NM_013369
NM_175867
DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

chr2_+_61404549 0.182 NM_152392
AHSA2
AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr19_+_54415990 0.180 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr19_-_11688484 0.178 ACP5
acid phosphatase 5, tartrate resistant
chr15_-_60919642 0.176 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr2_+_68592317 0.176 NM_002664
PLEK
pleckstrin
chr20_-_39766522 0.175


chr15_+_81489218 0.174 NM_001172128
IL16
interleukin 16
chr7_+_95115212 0.172 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr5_-_179072004 0.171 NM_001142306
C5orf60
chromosome 5 open reading frame 60
chr17_+_9729380 0.171 NM_004246
GLP2R
glucagon-like peptide 2 receptor
chr12_-_53730003 0.171 NM_001173467
SP7
Sp7 transcription factor
chr14_-_94759556 0.170 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr7_-_141541220 0.168 NM_001008270
NM_001171951
PRSS37

protease, serine, 37

chr2_-_65159566 0.168 LOC400958
uncharacterized LOC400958

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.